Yazar "Değirmenci, İrfan" için listeleme
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Akciğer Kanserli Hastalarda Plazma DNA Metiltransferaz ve Metil- CpG'ye Bağlanan Protein Seviyelerinin Değerlendirilmesi
Özbayer, Cansu; Üstüner, Derya Akyıldız; Ak, Güntülü Akdoğan; Saydam, Faruk; Metintaş, Muzaffer; Değirmenci, İrfan (2017)Amaç: Akciğer kanseri, akciğer doku hücrelerinin kontrolsüz çoğalmasıyla oluşan ölümcül bir hastalıktır. Çevresel faktörlerle birlikte genetik ve epigenetik değişikliklerin kanser gelişimine neden olduğu bilinmektedir. DNA ... -
Association and haplotype analysis of the PON1, ITGB3 and CYP3A4 genes, strong candidates for familial coronary artery disease susceptibility
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özbayer, Cansu; Ulus, Taner; Özdemir, Mahmut; Ata, Necmi; Güneş, Hasan Veysi (2023)Objective: Genetic predisposition is very common among the patients with coronary artery disease (CAD), a complex and multifactorial disease. Our objective was to determine the possible association between the most ... -
Association of paraoxonase 1 (PON1) gene polymorphisms and concentration with essential hypertension
Coşan, Didem Turgut; Çolak, Emine; Saydam, Faruk; Yazıcı, Hüseyin uğur; Değirmenci, İrfan; Birdane, Alparslan; Çolak, Ertuğrul; Güneş, Hasan Veysi (Taylor & Francis Inc, 2016)Human serum paraoxonase 1 (PON1) is carried by high-density lipoprotein in blood circulation and is shown to be effective in preventing oxidized phospholipids carried by low-density lipoprotein particles, thus it acts as ... -
Common variants rs3815188 and rs1043994 on notch3 gene confer susceptibility to lung cancer: A hospital-based case-control study
Yağcı, Emine; Değirmenci, İrfan; Özbayer, Cansu; Ak, Güntulu; Saydam, Faruk; Metintaş, Muzaffer (Begell House Inc, 2019)The Notch signaling pathway is a mechanism that plays a role in the determination of cell fate during cell development. Signals between neighbor cells are amplified through the Notch receptors. Notch activity is related ... -
The CYP 2C19*2 and CYP2C19*17 polymorphisms play a vital role in platelet responsiveness to clopidogrel after percutaneous coronary intervention: a pharmacogenomic study
Saydam, Faruk; Değirmenci, İrfan; Birdane, A.; Ozdemir, M.; Ulus, T.; Özbayer, Cansu; Çolak, E.; Ata, N.; Güneş, H.V. (Elsevier, 2015)Background: Clopidogrel inhibits platelet activation and aggregation by blocking the P2Y12 receptor. Dual antiplatelet therapy with clopidogrel and aspirin is recommended treatment by current guidelines for patients ... -
The CYP2C19*2 and CYP2C19*17 polymorphisms play a vital role in clopidogrel responsiveness after percutaneous coronary intervention: A pharmacogenomics study
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özdemir, Mahmut; Ulus, Taner; Özbayer, Cansu; Çolak, Ertuğrul; Ata, Necmi; Güneş, Hasan Veysi (Wiley, 2017)Clopidogrel inhibits platelet activation and aggregation by blocking the P2Y12 receptor. Dual antiplatelet therapy with clopidogrel and aspirin is recommended treatment by current guidelines for patients undergoing ... -
The effects of monosodium glutamate and tannic acid on adult rats
Çalış, İbrahim Uğur; Coşan, Didem Turgut; Saydam, Faruk; Kolaç, Umut Kerem; Soyocak, Ahu; Kurt, Hülyam; Güneş, Hasan Veysi; Şahintürk, Varol; Mutlu, Fezan Şahin; Köroğlu, Zeynep Özdemir; Değirmenci, İrfan (Kowsar Publ, 2016)Background: Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. the excessive use of MSG has been shown to increase oxidative stress in different organ systems and ... -
Haplotype analyses of CYP2C19*2 and CYP2C19*17 genetic polymorphisms in clopidogrel non-responsiveness after percutaneous coronary intervention with stent implantation
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özdemir, Mahmut; Özbayer, Cansu; Ata, Necmi; Güneş, Hasan Veysi (Nature Publishing Group, 2018).... -
Investigation of the cyp3a4 and pon1 gene variants in turkish patients with familial coronary artery disease
Saydam, Faruk; Değirmenci, İrfan; Birdane, Alparslan; Özdemir, Mahmut; Özbayer, Cansu; Ata, Necmi; Güneş, Hasan Veysi (Lippincott Williams & Wilkins, 2015)Objective: Coronary artery disease (CAD), a complex multifactorial disorder, has been suggested to be associated by the interaction of both environmental and genetic risk factors. -
Is the 1254T > C polymorphism in the DMT1 gene associated with Parkinson's disease?
Saadat, Selva Moheb; Değirmenci, İrfan; Özkan, Serhat; Saydam, Faruk; Köroğlu, Zeynep Özdemir; Çolak, Ertuğrul; Güneş, Hasan Veysi (Elsevier Ireland Ltd, 2015)Parkinson's disease (PD) is a late-onset neurodegenerative disorder with both familial and sporadic presentation. the main pathological characteristic of PD is the death of dopaminergic neurons in the substantia nigra (SN) ... -
miRSNPs of miR1274 and miR3202 genes that target MeCP2 and DNMT3b are associated with lung cancer risk: A study conducted on MassARRAY genotyping
Özbayer, Cansu; Değirmenci, İrfan; Üstüner, Derya; Ak, Güntulu; Saydam, Faruk; Çolak, Ertuğrul; Güneş, Hasan Veysi; Metintaş, Muzaffer (Begell House Inc, 2016)Genetic variants of miRNAs that target DNMTs and MBDs involved in DNA methylation were scanned with current databases, and 35 miRSNPs in 22 miRNA genes were identified. the aim of the study was to determine the association ... -
A promoter polymorphism in the PON1 gene is associated with essential hypertension
Coşan, Didem Turgut; Çolak, Ertuğrul; Saydam, Faruk; Yazıcı, Hüseyin Uğur; Değirmenci, İrfan; Birdane, Alparslan; Güneş, Hüseyin Veysi (Lippincott Williams & Wilkins, 2015)Objective: Increased vascular oxidative stress, the main risk factor of cardiovascular diseases, is seen as a role in the pathophysiology of essential hypertension. Genetic factors also play an important role in the ... -
Tannic acid exhibits anti-inflammatory effects on formalin-induced paw edema model of inflammation in rats
Soyocak, Ahu; Kurt, Hülyam; Coşan, Didem Turgut; Saydam, Faruk; Çalış, İbrahim Uğur; Kolaç, Umut Kerem; Koroğlu, Zeynep Özdemir; Değirmenci, İrfan; Mutlu, Fezan; Güneş, Hasan Veysi (Sage Publications Ltd, 2019)The aim of the study was to determine the relationship between anti-inflammatory effects of the natural polyphenolic compound tannic acid (CAS number: 1401-55-4) and myeloperoxidase (MPO) enzyme activity in paw edema model. ...